The requirement of these Basic courses in Molecular Medicine must reach at least 6 credits. 


The purpose of these courses is to extend the students’ knowledge of traditional Mendelian transmission genetics to include the molecular character of the gene, present the fundamentals of molecular genetics with emphasis on the structure and function of the nucleic acids, and apply the concepts of population genetics to human conditions, chromosome organization, molecular evolution, and conservation genetics.






Course B.1 The Frequency and Clinical Spectrum of Genetic Diseases
  • Patterns of inheritance
  • Spectrum of genetic diseases
  • Single gene defects
  • Chromosome abnormalities
  • Congenital malformation and common diseases: Multifactorial inheritance
  • Cytoplasmic inheritance
2 Credits
Course B.2 Structure, Organization, and Regulation of Human Genes
  • Structure of genes and the transmission of genetic information DNA
  • The regulation of gene expression
  • Coordinated gene expression (contact with the outside world)
1 Credit
Course B.3 The Techniques of Gene Analysis
  • Basic DNA manipulation methods
  • Speeding up the analysis of human DNA for diagnostic purposes
  • Studying the function of isolated genes
1 Credit
Course B.4 Finding Our Way Round the Human Genome
  • Approaches to human chromosome mapping
  • Genetic mapping of the human genome
  • Physical mapping techniques
  • Linking up genetic and physical maps; finding human genes
  • Reverse genetics
2 Credits
Course B.5 The Molecular Pathology of Single Gene Disorders
  • Types and levels of abnormal gene expression
  • Monogenic disorders resulting from the synthesis of an abnormal protein
  • Molecular lesions that result in the production of reduced gene products
  • Phenotype/genotype relationships for mutations that alter structural genes
  • The heterogeneity of monogenic disease summary
2 Credits
Course B.6 Molecular Genetics and Common Diseases
  • Approaches to the analysis of the molecular basis for polygenic disease
  • Diabetes
  • Other autoimmune diseases
  • Cardiovascular disease
  • Neuro-psychiatric disease
  • Hereditary variability in response to drugs
  • Infectious disease
  • Allergy and atopy
2 Credits
Course B.7 Cancer
  • Oncogenes and anti-oncogenes
  • How many mutations are required to produce a cancer cell?
  • Tumour immunology
  • Molecular aspects of cancer chemotherapy
2 Credits
Course B.8 Carrier Detection and Prenatal Diagnosis of Genetic Disease
  • The avoidance of genetic disease
  • Current methods for prenatal diagnosis
  • Sources of fetal DNA
  • How is fetal DNA analysed for single gene disorders?
2 Credits
Course B.9 Gene Therapy, Gene Cloning and Ethical Issues
  • Current methods for treatment of genetic disease
  • Gene replacement or corrective therapy
  • Specific ethical problems posed by the new genetics
2 Credits