PRE-IMPLANTATION GENETIC DIAGNOSIS/SCREENING (PGD/PGS)

Pre-implantation Genetic Diagnosis (PGD) is a state of the art technology with potential to increase the chance of having a healthy pregnancy. PGD is used to identify genetic defects in embryos created through ICSI before transferring them to the uterus. PGD is recommended when embryos may be affected by a certain genetic condition, and is proposed to fertile and infertile couples in conjunction with ART.

PGD is a means to genetically analyse a single cell from an 8-cell embryo or a blastocyst stage (biopsy) in order to determine more accurately if it is normal. Only healthy and normal embryos are transferred into the mother's uterus for implantation, thus preventing adverse outcomes such as miscarriages, pregnancy termination (after positive prenatal diagnosis, i.e., amniocentesis or chorionic villus sampling), or birth defects (physical and/or mental). This investigation greatly reduces the risk that these diseases will not be passed to their offspring and avoid an affected pregnancy. The reasons for requesting PGD include patients with chromosomal disorders and couples at risk of transmitting serious genetic disorders such as sickle cell anaemia. The most common type of PGS/PGD today involves testing for a panel of the most frequent chromosome abnormalities found in miscarriages and live born babies (chromosomes 13, 16, 18, 21, 22, X and Y). In certain circumstances, concomitant HLA typing is performed so that the resulting child will be free of the family’s genetic condition and be a compatible donor of cord blood stem cells to help treat an affected sibling.

Due to the complex and sophisticated technology and expertise involved, there are relatively few laboratories who propose PGS/PGD programmes. Fortunately, in our Centre, we have incorporated this state of the art technology for PGS and PGD for structural rearrangements, and we propose it as an option for anyone in need.

  • TITLE : Pre-implantation Genetic Diagnosis
  • TITLE : Pre-implantation Genetic Diagnosis
  • TITLE : Blastomere biopsy from day 3 embryo
  • TITLE : Blastomere biopsy from day 3 embryo